Osteogenesis Imperfecta

Osteogenesis imperfecta (OI), commonly known “brittle bone disease”, is an inherited connective tissue (collagen metabolism) disorder that causes bones to be more fragile than normal. Frequent fractures, skeletal deformities, dental problems (dentinogenesis imperfecta), hearing loss and short stature are common in this disease. In the mild form, children are followed only with fractures, whereas severe […]